If you have heard about Viagra, then you know Sildenafil. Sildenafil is the generic version of the popular erectile dysfunction brand Viagra, meaning you can refer to Sildenafil as Viagra’s “girl next door” sister.
Jokes aside, Sildenafil belongs to a group of medications known as phosphodiesterase-5 (PDE-5) inhibitors. Such drugs work by increasing penile blood flow to correct erectile dysfunction (ED).
Erectile dysfunction is pretty prevalent among men worldwide, with global statistics showing that it affects 322million men globally. Moreover, the USA features among the top five countries with the highest ED prevalence.
Erectile dysfunction is a serious reproductive and sexual health issue affecting men’s physical and psychological wellbeing. Sadly, despite the high prevalence rates, most ED cases go undiagnosed due to the social stigma attached to the condition.
Fortunately, Sildenafil is here to rescue all men suffering from ED in silence. So, keep reading to find out all there is to know about Sildenafil, including its benefits, cost, and how you can get it.
What is Sildenafil?
As stated above, Sildenafil is a generic version of Viagra and treats sexual dysfunction issues that lead to erectile dysfunction among adult men. It is among the main oral therapy prescription medications for men. However, it does not alleviate sexual dysfunction issues among women and is not ideal for such use among women.
The generic drug’s production began in 2017, a year before Viagra’s 30th anniversary.
Pfizer, Viagra’s manufacturer, authorized Greenstone, one of its subsidiaries, to commence Sildenafil production. The pharmaceutical giant’s motivation in authorizing Viagra’s generic bioequivalent’s production is to make ED oral therapy more affordable since Viagra’s price made treatment inaccessible to many market niches.
|Effect||✓ Increases the erection||
✓ Improves male’s sexual performance
|Possible risks||X Many risks||✓ No risks|
|Dosage||depends of prescribed dosage||1 capsule per 24 hours|
|Price|| from $22,00
|Shipping||Not Available Online||✓ FREE WORLDWIDE|
|Reviews||⭐⭐⭐ 3/5||⭐⭐⭐⭐⭐ 5/5|
|Delivery time||X||✓ 1-3 Days|
As a generic drug, Sildenafil is more affordable, yet it also contains Sildenafil citrate as its active ingredient. One patient survey shows that at least two-thirds of men using Sildenafil to treat ED reported satisfactory results.
Besides Viagra, Sildenafil is also the generic version of the drug Revatio, used in treating pulmonary arterial hypertension (PAH). Although doctors may only prescribe Sildenafil for ED to Adult males aged 18 and over, the case is different for pulmonary arterial hypertension diagnoses. For the latter, doctors may prescribe Sildenafil to men, women, and children over one year old and battling the pulmonary condition.
What are the ingredients of Sildenafil?
Sildenafil’s key active ingredient is a pharmacological compound called Sildenafil citrate. However, besides Sildenafil citrate, the drug contains inactive ingredients that make it more palatable and increase its bioavailability. A drug’s bioavailability refers to the amount of that drug that makes it to the target cells within the shortest time possible, delivering associated relief.
- Microcrystalline cellulose
- Anhydrous dibasic calcium phosphate
- Croscarmellose sodium
- Magnesium stearate
- Titanium dioxide
- Artificial colors
How does Sildenafil work? How good is the effect of Sildenafil?
As stated above, Sildenafil belongs to a group of medications called phosphodiesterase-5 inhibitors. PDE-5 inhibitors work by mitigating the biological factors that may cause erectile dysfunction.
Erectile dysfunction has physical, lifestyle, and physiological causes. Such causes include age, diabetes, hypertension, high cholesterol and obesity, medication use, alcohol, recreational drug use, and stress and anxiety. So, ED may also be a symptom of a serious underlying health issue, hence why Sildenafil is a prescription drug requiring an initial medical exam.
Regardless of your ED’s root cause, the result is an inability to achieve and maintain an erection. Therefore, to understand Sildenafil’s pharmacological effect, begin by understanding the biological processes that lead to an erection.
An erection begins during sexual arousal. Once the peripheral nerve cells receive signals of sexual arousal, they transmit the signals to the section of the brain that processes pleasure signals. The brain responds by activating nitrogen oxide (NO) production in the endothelial cells of the corpus cavernosum.
The corpus cavernosum is the soft tissue that gives a penis its limb look before arousal. It features two major arteries connecting arteries and capillaries that run throughout the tissue mass and function as an erection chamber.
The NO release activates an activating protein called guanylyl cyclase to initiate guanosine triphosphate into (GTP) conversion into cyclic guanosine monophosphate (cGMP).
cGMP causes the blood vessel walls in the corpus cavernosum to relax as the blood vessels in the rest of the body contact. Its relaxation effect on the blood vessels causes increased blood flow to the penis, making the penis firm and erect.
An orgasm or climax in sexual activity signals the brain to activate the release of phosphodiesterase-5, a compound that causes cGMP to disintegrate. As the cGMP levels plummet, the corpus cavernosum’s blood vessel walls contract, causing blood to flow away from the penis, and the penis turns limb again.
So, erectile dysfunction may result from either one of two factors. First, it may result from hampered communication between the brain and the peripheral nerve cells, inhibiting NO release in the corpus cavernosum. Second, poor signal transmission may also cause premature PDE-5 production, causing cGMP to start disintegrating way before an organism.
Consequently, Sildenafil features a two-way pharmacological effect to counter both ED factors. First, it improves cell-to-cell communication, ensuing optimum NO production to trigger the erection cycle. Second, Sildenafil also inhibits premature PDE-5 release, facilitating a sustained erection.
Sildenafil reaches peak plasma concentrations within 30 minutes to an hour of consumption and lasts up to five hours. After five hours, the effects begin to wear off, losing 50% of its strength every four hours. The gradual way Sildenafil loses tapers off from the body makes it ideal for on-demand use and daily use.
Doctors recommend taking Sildenafil for ED treatment between an hour and four hours before engaging in sexual activity. However, Sildenafil for off-label PAH treatment follows a different set of rules that your doctors should explain.
One prevalent misconception about Sildenafil is that it is an aphrodisiac. We take this opportunity to debunk that myth and clarify that Sildenafil is a PDE-5 inhibitor and requires sexual stimulation to take effect.
Sildenafil clinical studies evaluation & results 2021: Is Sildenafil safe to use?
There have been several clinical studies done to prove the efficacy of Sildenafil. One of them found that the 50mg dosage worked for up to 74% of men with erectile dysfunction. Another one shows that the 100mg dosage works better and is effective for about 82% of men with erectile dysfunction.
How do you use and dose Sildenafil? Our dosage recommendation:
Sildenafil comes in three dosage strengths of 25mg, 50mg, and 100mg. But most people will have a prescription for 50mg. However, when used off-label to treat PAH, it is available in four different dosage strengths of 2.5mg, 5mg, 10mg, and 20mg.
Note that the dosage strength information above is primarily for general information because Sildenafil is a prescription drug. Therefore, you need to visit your primary care physician (PCP) or any other certified medical doctor allowed to write prescriptions.
The doctor should review your medical history and conduct a physical exam to ensure that your ED is not an adverse health issue symptom. Second, they also need to determine Your ED’s severity to evaluate whether you qualify for oral ED therapy or other forms of ED treatment.
However, if the procedures above seem too intrusive for your liking, you can opt to use reputable telehealth services run by licensed doctors. Once you sign up or log onto a telehealth platform, you will receive a questionnaire, fill it, and submit it for review. Once a doctor reviews your questionnaire, they will set up a virtual appointment, ask follow-up questions, and issue the Sildenafil prescription.
Doctors consider age, overall health, lifestyle issues, and pre-existing diagnoses to determine individual-specific Sildenafil dosages. Therefore, all you need to do is follow your doctor’s prescription directive to the T.
For starters, you shouldn’t take more than a tablet in 24 hours or more than the maximum 100mg dose for ED. However, if you take Sildenafil for PAH treatment, take the prescribed dose three times a day. Some other precautions to bear in mind when taking Sildenafil are as follows:
- Eat more than an hour before taking it and try and avoid fatty foods
- Don’t take more than a glass or two of wine
- Whatever dosage you are on, do not take more than one pill at a go
- Take the tablet at least one hour before you intend to have sex
- You will need to be sexually aroused for the drug to work.
- Do not take more than the dosage the doctor prescribed. If you feel the dosage isn’t working, speak to your doctor first and let them be the one to increase your dosage.
Some people believe that chewing Sildenafil makes the drug work faster; the misconception is probably from the presence of chewable Sildenafil tablets in the market. On the contrary, while you can chew, crush, or swallow your Sildenafil whole, chewing or swallowing the tables does not expedite their activity. The primary factors that affect how long Sildenafil takes to work are food and physiological factors like age and body weight.
Our Sildenafil review and rating: Sildenafil Pros and Cons:
Sildenafil users have different opinions on how the drug works on them. Some of them cannot start singing its praises, while others don’t feel like it works at all. Here is what some trust pilot reviewers had to say.
- Sildenafil positive review
- Sildenafil negative review
Sildenafil Results Before and After: Does Sildenafil really work or is it a scam?
Given that Sildenafil is a generic drug, some people may have reservations about using it. The ever-increasing volume of counterfeit Sildenafil tablets sold online does not help matters. However, if you fulfill your Sildenafil prescription from an above-board pharmacy, you should see tremendous improvement within eight weeks as follows.
Sildenafil results after two weeks:
|After using Sildenafil for two weeks straight, you may still experience some performance anxiety. However, try to keep calm and enjoy the moment because situational anxiety may interfere with Sildenafil’s effectiveness. Otherwise, you should experience firm erections each time.|
Sildenafil results after four weeks:
|Continuous satisfactory results achieved from four straight weeks of using Sildenafil tablets should help you overcome situational and performance anxiety completely. The rock-solid and sustainable erections should persist.|
Sildenafil results after six weeks:
|At six weeks of Viagra use, you can comfortably say that you’ve gotten your groove back. Your refractory period (the window between ejaculation and a subsequent erection) should be shorter, allowing you to enjoy several rounds of sexual activity. The spontaneity should keep you and your sexual partner deeply satisfied.|
Sildenafil results after eight weeks:
|Besides the above-mentioned positive developments, you should also have better ejaculatory control and full confidence in your sexual capabilities. It will be like ED never happened in the first place.|
Sildenafil Reviews on the internet and in forums:
Was Sildenafil in Shark Tank?
Sildenafil got a lot of traction from being a generic version of Viagra. It is just as effective for a really good price. For this reason, it didn’t need the publicity that comes with shark tank.
Is Sildenafil legit, or are there any warnings about Sildenafil on the Internet?
However, Sildenafil is safe as long as you use it for the right problem and recommended doses. Recreational Sildenafil use often results in adverse effects for the user.
Where to buy Sildenafil? Sildenafil for Sale offer & price comparison
Can you buy Sildenafil in the pharmacy?
Yes. Sildenafil is a prescription drug. You should see a doctor and get a prescription. Although there are many places you can get it online, it is advisable to buy a pharmacy for authenticity’s sake. Alternatively, you can have your doctor fulfill your prescription for you so that you receive the pills at your doorstep or a recommended reputable pharmacy.
Besides pharmacies, several online platforms offer ED treatment coupon codes for various ED oral medications, including Sildenafil. The coupons allow you to save up to 70% off the retail price when you fulfill your Sildenafil prescription via select reputable telehealth platforms.
What do I have to consider if I want to discontinue Sildenafil?
Sildenafil Review Conclusion – Our experiences and recommendation:
Although it is the generic version of a pretty popular drug, there is nothing inferior about Sildenafil. It is just as effective as household oral therapy medications used in treating erectile dysfunction. Moreover, it has the advantage of being substantially cheaper than brand names like Viagra, which feature a similar active ingredient.
Various peer review journals and thousands of reviews posted on trusted review websites vouch for its effectiveness. Therefore, we recommend that all male adults aged 18 years and seeking affordable ED medication consult a PCP and receive a Sildenafil medication.
Frequently asked questions about Sildenafil:
When buying a new drug, there are things you would like to know in advance. We’ve put together a few of the common questions you may have.
Is Sildenafil recommendable or are there any criticisms of Sildenafil?
Are there any Sildenafil deals or coupon codes?
Who is behind the manufacturer of Sildenafil?
Does Sildenafil have any risks or side effects?
Is the continuous use of Sildenafil safe?
Can you buy Sildenafil on eBay & Amazon?
Do I need a prescription to buy Sildenafil?
How much does Sildenafil cost and where can I buy Sildenafil with the cheapest price?